Table 8-7016.

Referenced Multivariate Epidemiology Study Examining Metabolic Syndrome Risk Factors and Cancer Incidence/Mortality for Endometrial Cancer

Study	Xu et al, 200624
Results (relative risk ratio 95% CI)	Pre recent BMI Q4 (≥25.69 kg/m2) versus Q1 (<21.03 kg/m2): 3.6 (2.2, 5.9)*; Post recent BMI (≥25.69 kg/m2) versus Q1 (<21.03 kg/m2): 2.7 (1.8, 4.1)*; Pre BMI change/year since age 20 (>0.189 versus ≤0.049 kg/m2): 3.4 (2.0, 5.8)†; Post BMI change/year since age 20 (>0.189 versus <0.049 kg/m2): 2.7 (1.8, 4.2)†; Pre weight change (kg) since age 20 (gain >20 kg versus loss/gain <2.5 kg): 3.1 (1.8, 5.5); Peri weight gain with BMI <25 kg/m2 (gain >5 versus ≤0 kg): 2.3 (1.4, 3.9); Peri weight gain with BMI ≥25 kg/m2 (gain >5 versus ≤0 kg): 2.0 (1.3, 3.0); Post weight change (kg) since age 20 (loss >2.5 kg versus loss/gain <2.5 kg) 0.4 (0.2, 1.0)
	Pre weight change (kg) since age 20 (gain >20 kg verus loss/gain <2.5 kg); 2.8 (1.4, 5.7)
Size and type	Chinese women cases n = 832, controls n = 846; case control study
Covariates	Education; menstrual status; years of menstruation; oral contraceptive use; number of pregnancies; family history of cancer; adolescent perceived weight or height at ages 10, 15, and 20; age; BMI at age 20; and initial body weight in each 10-year adulthood period
Exclusion	Hysterectomy
Nonsignificant studies	BMI at ages 20 and 30 (post), at age 50 (pre); Weight gain at age 20 (post); Perceived weight at ages 10, 15, and 20 (BMI <25 kg/m2)
Other significant studies not listed here	BMI at ages 20 and 30 (pre), at ages 40, 50, and 60 (pre and post); Weight gain from ages 20 to 30 (pre); at ages 30 to 40 (pre and post); from ages 40 to 50, and 50 to 60 (post); Perceived weight at ages 10, 15, and 20 (BMI <25 kg/m2); weight change from age 20 to recent (all BMIs)

Pre, premenopausal; Post, postmenopausal; Peri, perimenopausal. 

^*P < 0.01. 

^†P < 0.0001.