Figure 2.

Analyses of paired samples of blood (B) and synovial fluid (SF) B cells from the same rheumatoid arthritis patient. Results using both the genomic DNA-based assay and the complementary (c)DNA-based assay for the three major immunoglobulin isotypes (M, G, and A) are shown. Note that certain clones, as represented by individual HCDR3 lengths, are restricted to the blood (▸), others to the joint (▹), and others are common to both compartments (♦). E, expanded clone; A, activated clone; E+A, same clone that is both expanded and activated.