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Analyses of B cells from paired samples of blood (B) and synovial tissue from both the right (R) and left (L) hips of the same rheumatoid arthritis patient. Results using both the genomic DNA-based assay and the complementary (c)DNA-based assay for the three major immunoglobulin isotypes (M, G, and A) are shown. R, clones that are restricted to the right hip joint; L, clones that are restricted to the left hip joint; R+L, clones that are common to both the right and left hip joints.
