Table 2.
Effects of mast cell activation on cytokine production by explanted rheumatoid synovial tissue
| Tryptase | TNF-α | IL-β | IL-15 | ||||||
| Sample | Control | Anti-IgE | Control | Anti-IgE | Control | Anti-IgE | Control | Anti-IgE | |
| 753 | 11.1 | 30.4 | 138 | 6.4 | 24.2 | 4.1 | 0.31 | 0.28 | |
| 764 | 28.1 | 181.6 | 271 | 204 | 11.4 | 20.9 | 0.55 | 0.4 | |
| 770 | 8.6 | 46.6 | 12.8 | 276 | 30.3 | 11.9 | 0.54 | 0.54 | |
| 773 | 8.9 | 47.9 | 103 | 8.5 | 19.1 | 5.8 | 0.27 | 0.3 | |
| 798 | 32.3 | 42.1 | 97.8 | 34.6 | 165.3 | 38 | 0.52 | 0.49 | |
| Averaged values | 17.8 | 69.7 | 177.2 | 53.2 | 50.1 | 16.1 | 0.44 | 0.40 | |
Values expressed as ng/ml per 100 mg tissue per 20 h for tryptase and as pg/ml per 100 mg tissue for cytokines. For tryptase P = 0.05, for tumour necrosis factor-α P = 0.02, and for interleukin (IL)-1β P = 0.28, by Student's T-test. Ig, immunoglobulin.