Table 2.

CII-induced IFN-γ response is major histocompatibility Complex (MHC) class II restricted

	No ab	Class II ab	Control ab
CII	100	10 (6–22)	75 (66–125)
PPD	100	13 (8–32)	109 (63–123)
influenza	100	7 (4–15)	95 (68–125)

Peripheral blood mononuclear cells from two rheumatoid arthritis Patients and three healthy controls were stimulated with native Collagen type II (CII), influenza virus or purified protein derivative in the Presence of antibodies (ab) specific for major histocompatibility Complex-class II or isotype-matched control antibodies. Supernatants Were collected after 7 days of culture and the concentration of IFN-γ was analysed by enzyme-linked immunosorbent assay. Values are expressed as median % (range) of cytokine present in Supernatants of which no antibodies were added.