Table 2.
GPx-3 promoter haplotype frequencies and pairs among study subjects
| Haplotype Frequency | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Adults |
Children |
|||||||||||
| Haplotype | -942 A→C | -927 T→C | -861 A→T | -568 T→C | -518 T→C | -302 A→T | -284 T→A | -65 T→C | Controls (n=123) | Patients (n=123) | Controls (n=82) | Patients (n=82) |
| H1 | A | T | A | T | T | A | T | T | 84.9% | 79.6% | 86.0% | 79.3% |
| H2 | C | C | T | C | C | T | T | C | 7.0% | 13.1% | 7.9% | 13.4% |
| H3 | A | T | A | T | T | A | A | T | 6.2% | 2.9% | 4.3% | 3.7% |
| H4 | C | C | T | T | T | A | T | T | 0.8% | 2.1% | 1.2% | 1.2% |
| H5 | A | T | A | C | C | T | T | C | 0.4% | 1.2% | 0.6% | 1.2% |
| H6 | A | T | A | T | T | A | T | C | 0.4% | 0.4% | 0 | 0.6% |
| H7 | C | C | T | C | C | T | A | C | 0.3% | 0.3% | 0 | 0 |
| H8 | C | C | T | T | T | A | T | C | 0 | 0.4% | 0 | 0.6% |
| The position of each polymorphism is based on the transcription start site being +1. | ||||||||||||
| Haplotype pairs | ||||
|---|---|---|---|---|
| Adults | Children | |||
| Haplotype pair | Controls (n=123) | Patients (n=123) | Controls (n=82) | Patients (n=82) |
| H1/H1 | 89 (72.4%) | 76 (61.8%) | 60 (73.2%) | 48 (58.5%) |
| H1/H2 | 14 (11.4%) | 28 (22.8%) | 12 (14.6%) | 22 (26.8%) |
| H1/H3 | 12 (9.8%) | 6 (4.9%) | 6 (7.3%) | 6 (7.3%) |
| H1/H4 | 2 (1.6%) | 3 (2.4%) | 2 (2.4%) | 2 (2.4%) |
| H1/H5 | 1 (0.8%) | 3 (2.4%) | 1 (1.2%) | 2 (2.4%) |
| H1/H6 | 1 (0.8%) | 1 (0.8%) | 0 | 1 (1.2%) |
| H1/H7 | 0 | 1 (0.8%) | 0 | 0 |
| H1/H8 | 0 | 1 (0.8%) | 0 | 1 (1.2%) |
| H2/H2 | 1 (0.8%) | 1 (0.8%) | 0 | 0 |
| H2/H3 | 2 (1.6%) | 1 (0.8%) | 1 (1.2%) | 0 |
| H2/H4 | 0 | 2 (1.6%) | 0 | 0 |
| H3/H3 | 1 (0.8%) | 0 | 0 | 0 |
Carriers of the GPx-3 promoter H1H1 haplotype pair were used as the reference group.