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. 2007 Jan 8;8:1. doi: 10.1186/1471-2156-8-1

Table 2.

Simulation results for clustering of biallelic effects using our presentation (eq. (1)) of the infinite alleles model when markers are fully informative. 100 replicates were simulated for each QTL effect

Percentage of the phenotypic variance explained by the QTL Proportion correctly clustered allele effects Cluster differencea Estimated allelic QTL varianceb (12σv2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabikdaYaaaiiGacqWFdpWCdaqhaaWcbaGaemODayhabaGaeGOmaidaaaaa@32FC@) Estimated dominance variance (σd2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGaemizaqgabaGaeGOmaidaaaaa@30E6@) Estimated residual variance
5% additive QTL 0.79 2.63 (0.81) 2.65 (1.16) - 95.11 (4.85)
10% additive QTL 0.93 3.93 (0.73) 4.99 (1.58) - 89.85 (4.97)
20% additive QTL 0.97 5.91 (0.65) 9.89 (2.44) - 78.98 (3.87)
20% add. and 10% dom 0.99 5.39 (1.85) 9.61 (4.46) 10.98 (3.1) 70.43 (2.56)

a Average differences between cluster means. Standard deviations within parentheses

b The allelic variance is estimated from model (1). The expected mean is half the proportion of the total variance explained by the QTL.