Table 2.

The four trials

TRIAL	SPECIALTY	POPULATION	MANAGEMENT	RECRUITMENT SETTING	INTERVENTIONS	DESIGN	FUNDERS
HPS (The Heart Protection Study)	Cardiovascular health promotion	Patients at increased risk of coronary heart disease	Clinical Trials Unit	Hospital	- Statins (Simvastatin) -Antioxidant vitamins - Placebo	4 arm randomised trial (2 × 2 factorial)	MRC BHF Industry
FOCUS (Trial of Chemotherapy for Bowel Cancer (Fluorouracil, Oxaliplatin and Irinotecan (CPT11), Use and Sequencing)	Oncology	Patients with advanced metastatic colorectal cancer	Clinical Trials Unit	Hospital	Chemotherapeutic agents - Modified de gramont with fluorouracil - Irinotecan - Oxaliplatin	5 arm randomised trial with cross-over	MRC Industry NHS Trusts
ELEVATE (A pragmatic single-blind RCT and health economic evaluation of leukotriene receptor antagonists in primary care at steps two and three of the National Asthma Guidelines)	Asthma management	Primary care patients with asthma requiring regular preventative treatment or an increase in therapy	University Department	General Practice	- Leukotriene receptor antagonists - Inhaled corticosteroids - long-acting beta agonists	3 arm randomised trial (with option to switch treatments post-randomisation and parallel non-randomised 'naturalistic' cohort for patients refusing randomisation)	HTA Industry PCTs
TOuCAN (Trial of Outcome for Child &Adolescent Anorexia Nervosa)	Adolescent psychiatry	Adolescents (aged 12–18) with anorexia nervosa	Hospital/university	Hospital and out-patient service	- intensive inpatient treatment - general local outpatient service - specialist outpatient service	2 severity strata (steps) with 2 arms at each step	HTA