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. 2006 Oct 27;35(Database issue):D751–D755. doi: 10.1093/nar/gkl748

Figure 1.

Figure 1

Concepts and data used in the EPConDB web site. DoTS Transcripts, which are consensus sequences generated by the assembly of ESTs and mRNAs, are associated with elements on microarray platforms based upon their GenBank accession numbers and RefSeqs. Using the arrays, gene expression is determined under multiple experimental conditions. For the PromoterChip, the tiles are assigned DoTS transcripts based upon Entrez Genes. Transcription factor binding site predictions are made in regions conserved between human and mouse that are in or near a PromoterChip tile. Using the PromoterChip, binding sites can be determined experimentally and employed to validate binding site predictions. Overall, the relationship between a gene, its transcriptional regulation and expression under various conditions can be examined. The colored lines represent sequences used to create a DoTS transcript, black lines represent mRNAs or RefSeqs, grey lines ESTs, red lines represent annotated 5′ ESTs and blue lines annotated 3′ ESTs.