Table 1.
PPI datasets currently integrated in UniHI
| Dataset | Proteins | Interactions | Method | References | Database location |
|---|---|---|---|---|---|
| MDC-Y2H | 1703 | 3186 | Y2H screen | (12) | www.mdc-berlin.de/neuroprot |
| CCSB-Y2H | 1549 | 2754 | Y2H screen | (13) | vidal.dfci.harvard.edu (flat file only) |
| CCSB-LIT | 2192 | 4067 | Text mining | (13) | vidal.dfci.harvard.edu (flat file only) |
| HPRD-BIN | 5908 | 15 508 | Literature | (8) | www.hprd.org |
| HPRD-COMP | 1277 | 4468 | Literature | (8) | www.hprd.org |
| DIP | 1033 | 1303 | Literature | (7) | dip.doe-mbi.ucla.edu |
| BIND | 4273 | 5863 | Literature | (6) | www.bind.ca |
| COCIT | 3737 | 6580 | Text mining | (10) | bioinformatics.icmb.utexas.edu/idserve |
| REACTOME | 679 | 12 639 | Literature | (16) | www.reactome.org |
| ORTHO | 6225 | 71 466 | Orthology | (11) | www.sanger.ac.uk/PostGenomics/signaltransduction/interactionmap |
| HOMOMINT | 4127 | 10 174 | Orthology | (17) | mint.bio.uniroma2.it |
| OPHID | 4785 | 24 991 | Orthology | (9) | ophid.utoronto.ca |
Number of proteins and interactions in each dataset as well as construction approach are given.