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Periarticular injection of Ad-mIL-4 into the hind leg ankle joints conferred a therapeutic effect in the untreated, front paws. The arthritic mice injected in the hind leg ankle joints with Ad-mIL-4, Ad-eGFP or saline were evaluated for the severity of arthritis in either the hind, treated paws (a) or front, untreated paws (b). The macroscopic score (mean ± standard deviation) is expressed as a cumulative value for the two paws, with a maximum possible score of 8.
