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Levels of expression of IL-4 and IL-10 in immunized mice after periarticular injection of diferent doses of Ad-mIL-4. Increasing doses of Ad-mIL-4 were injected periarticularly into mice with established arthritis. The animals were killed at day 35, and the joint tissue homogenized and assayed for levels of (a) IL-4 and (b) IL-10. The doses of Ad-mIL-4 used were as follows: low, 5×106; mid, 5×107; and high, 5×108.
