Figure 2.

Analyses of the VH4 family amplificates. (a) Comparison of the five nucleotide VH4 sequences with their germline counterpart IgHV4-30-1/4-31^*02. (b) Clonal relation between sequences k194/100 and k194/101; replacement (r) and silent (s) mutations on the VH segment when compared with the germline. (c) Clonal relation between sequence k194/23 amplified from the left peroneal tendon (lpt) and sequences k194/102 and k194/103 amplified from the cubita. Dashed arrows indicate the possibility of cyclic re-entry of the mature B cells into the hypermutation process.