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Kinetic parameters from the spectrophotometric assay for hydrolysis of peptide Ac-KARVNle(Phe-p-NO2)EANle-CO-NH2 and inhibition by TMC114 of PR, PRV32I and PRM46L.
| Protease | Km, μM | kcat, min−1 | kcat/Km, min−1·μM−1 | Ki, nM (Relative) |
|---|---|---|---|---|
| PR | 106 ± 9 | 245 ± 10 | 2.3 ± 0.2 | 0.49 ± 0.13 (1) |
| PRV32I | 90 ± 8 | 198 ± 6 | 2.2 ± 0.2 | 3.3 ± 0.2 (6.7) |
| PRM46L | 286 ± 23 | 283 ± 11 | 1.00 ± 0.08 | 4.9 ± 0.4 (10) |
