Figure 4.

Overview of an ≈1.2-Mb-long inversion on chromosome 10 predicted in the CHB + JPT analysis panel. Also shown are two fosmid pairs (discordant by orientation) whose one end maps to before the predicted left breakpoint and the other end maps to a region before the right breakpoint. These discordant mappings support the predicted inversion breakpoints. In this region, there is another overlapping inversion predicted in the CHB + JPT analysis panel. The region has several genes proximal to the left breakpoint, one of which is known to be overexpressed in tumor cells (Sampath et al. 2003).