Figure 3.

Serum levels of antibodies specific for CII. Comparison of isotype anti-CII IgG responses in thymectomized (Tx) and sham-operated (Sham) mice as measured in sera 35 days after immunization in MMC transgenic mice and the nontransgenic littermates. Open symbols represent IgG_2a and filled symbols IgG₁. The transgenic mice have significantly lower isotype levels compared with their nontransgenic littermates, but thymectomy had no effect. The same pattern was seen in female (A) and male (B) mice.