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B-cell response to CII. IgG ELISPOT is an assay that enumerates the number of anti-CII antibody-producing cells present in the LNCs. Squares represent individual nontransgenic littermates and triangles represent the transgenic MMC mice. No difference before and after thymectomy was noted and the difference between MMC and wild-type mice are significant (P =0.0012 for all mice, P =0.0102 for thymectomized mice). TX, thymectomized.
