Table 1.

Development of CIA and antibody responses to CII

			Arthritis	Onset (day		Anti-CII IgG (μ g/ml
			(frequency of	max score of		in serum 35 days
Sex	Mice		CIA)	arthritic mice)	Severity	after immunization)
Male	Lm	Sham	11/11	25 ± 4	8.4 ± 1.5	182 ± 73
		Tx	9/9	33 ± 9	9.1 ± 2.0	328 ± 206
	MMC	Sham	2/8	34 ± 6	4.5 ± 5.0	63 ± 112
		Tx	3/8	56 ± 22	2.0 ± 1.0	40 ± 49
Female	Lm	Sham	6/7	35 ± 15	7.2 ± 2.8	614 ± 413
		Tx	7/8	43 ± 16	7.6 ± 3.0	423 ± 273
	MMC	Sham	0/8	-	-	30 ± 25
		Tx	2/10	64 ± 1.4	3.0 ± 2.8	24 ± 33

lm, nontransgenic littermates; Sham, sham-operated; Tx, thymectomized. Where applicable, values are expressed as mean ± standard deviation.