Table 1.
Effect of PVN stimulation on cardiorespiratory variables after intracisternal blockade of OT receptors.
| Drug | DEMG (Au) | Min DEMG | Ti (s) | Te (s) | f (breaths/min) | GGEMG (Au) | Min GGEMG | BP (mmHg) | HR (bpm) |
|---|---|---|---|---|---|---|---|---|---|
| ControlBaseline | 0.38 ± 0.05 | 18.6 ± 2.6 | 0.22 ± 0.02 | 1.01 ± 0.05 | 49 ± 2 | 0.60 ± 0.10 | 30 ± 5 | 110 ± 6 | 415 ± 10 |
| AVT | 0.37 ± 0.05 | 18.4 ± 2.8 | 0.24 ± 0.02 | 0.99 ± 0.08 | 50 ± 3 | 0.62 ± 0.13 | 31 ± 5 | 112 ± 7 | 426 ± 11 |
| Bicuculline | 0.38 ± 0.05 | 19.4 ± 2.9 | 0.22 ± 0.02 | 0.99 ± 0.07 | 51 ± 3 | 0.49 ± 0.09 | 25 ± 4 | 107 ± 5 | 430 ± 11* |
Values are means ± SE; n = 7 animals.
Differences between baseline and changes induced by AVT were not significant (P>0.05). Bicuculline administration did not significantly change (P>0.05) the values recorded post AVT. Heart rate for microinjection of bicuculline was significantly elevated above the baseline value (P<0.05).