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. Author manuscript; available in PMC: 2008 Jan 1.
Published in final edited form as: J Appl Physiol (1985). 2006 Jul 20;102(1):189–199. doi: 10.1152/japplphysiol.00522.2006

Table 2.

Effect of PVN stimulation on cardiorespiratory variables after blockade of OT receptors in preBötC

Drug DEMG (Au) Min DEMG Ti (s) Te (s) f (breaths/min) GGEMG (Au) Min GGEMG BP (mmHg) HR (bpm)
ControlBaseline 0.46 ± 0.07 24.0 ± 3.7 0.26 ± 0.02 0.91 ± 0.07 53 ± 3 0.49 ± 0.03 25.7 ± 2.1 106 ± 6 426 ± 6
   L-368899 0.39 ± 0.07 19.8 ± 3.7 0.25 ± 0.02 0.94 ±0.06 51 ± 3 0.40 ± 0.04 20.7 ± 2.2* 92 ± 6* 422 ± 7
  Bicuculline 0.35 ± 0.07 18.3 ± 3.7 0.21 ± 0.04 0.97 ± 0.09 52 ± 3 0.38 ± 0.06 * 19.7 ± 3.2* 93 ± 7 417 ± 5

Values are means ± SE; n=6 animals.

*

Represents differences (P < 0.05) between baseline and after administration of L-368899 for Min GGEMG and arterial blood pressure (BP). Differences between values post L-368899 and bicuculline were not significant (P>0.05) indicating that blockade of OT receptor within the preBötC inhibited responses elicited by PVN stimulation. Represents a significant difference (P<0.05) between the treatment and baseline value.