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Example false positive curves. Number of falsely implicated differentially expressed genes with rank ≤ x for the simple t-test, fold change cut-off, SMT, Fox, and IBMT methods. Figure shows the accumulation of false positives by gene rank. Data shown is the average of 100 simulations using (A) the high-strength dependence of variance on expression level and 100 prior degrees of freedom, and (B) the mid-strength dependence and 1 prior degree of freedom.
