Table 2.
Top significant Gene Ontology categories for the MEF Ahr-/- dataset
| Top 10 GO | t-test | FOLD | SMT | IBMT |
| 1 | Extracellular space (77) | Extracellular (91) | Extracellular (90) | Extracellular (92) |
| 2 | Extracellular (84) | Extracellular space (82) | Extracellular space (81) | Response to biotic stimulus (39) |
| 3 | Integrin binding (5) | Signal transducer activity (67) | Receptor binding (27) | Extracellular space (80) |
| 4 | Spermine/Spermidine biosynthesis (3) | Organogenesis (38) | Chemoattractant activity (8) | Response to external stimulus (46) |
| 5 | Carboxy peptidase activity (6) | Chemoattractant activity (7) | Signal transducer activity (68) | Defense response (34) |
| 6 | Spermidine metabolism (3) | Receptor binding (24) | Response to biotic stimulus (33) | Signal transducer activity (68) |
| 7 | Polyamine biosynthesis (3) | Histogenesis and organogenesis (9) | Chemokine receptor binding/activity (7) | Chemoattractant activity (8) |
| 8 | Receptor binding (22) | Morphogenesis (39) | Integrin binding (5) | Immune response (27) |
| 9 | Adenosylmethionine decarboxylase activity (2) | Serine-type endopeptidase inhibitor activity (9) | G-protein-coupled receptor binding (7) | Response to pest/pathogen/parasite (19) |
| 10 | Spermine metabolism (3) | glycosaminoglycan binding (7) | Spermine/Spermidine biosynthesis (3) | Chemokine receptor binding/activity (7) |
| # Bonf<0.1 | 6 | 8 | 13 | 17 |
| # genes ↑ | 92 | 142 | 135 | 144 |
Top ten categories for each of the four compared methods: magnitude of fold change, simple t-test, SMT, and IBMT. The IBMT method resulted in both the highest number of significant categories using a 0.10 Bonferroni-adjusted p-value cut-off, as well as the highest number of genes in a significant category.