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. 2007 Jan 12;3(1):e5. doi: 10.1371/journal.pgen.0030005

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© 2007 Susiarjo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) For unexposed animals, there was no difference in mean number of MLH1 foci/cell between wild-type (26.3 ± 3.0) and heterozygous (25.8 ± 2.8) females, but unexposed mutants (28.7 ± 3.2) were highly significantly increased over wild type (t = 6.0; p < 0.001). These data represent the results from five unexposed pregnant females. For +/+ animals, 124 cells were analyzed from four females; for +/−, 44 cells from three females; and for −/−, 114 cells from four females. Data are provided as mean ± standard deviation.

(B) Among exposed animals, the mean values for the three genotypes were virtually identical, but all had highly significantly elevated means over that of unexposed wild-type animals (28.6 ± 3.5, t = 3.5, p < 0.001; 28.1 ± 3.5, t = 4.5, p < 0.001; 28.1 ± 3.5, t = 3.9, p < 0.001 for +/+, +/−, and −/−, respectively). These data represent the results from six pregnant females implanted with BPA pellets. For +/+ animals, 35 cells were analyzed from two females; for +/−, 136 cells from six females; and for −/−, 89 cells from five females. Data are provided as mean ± standard deviation.