. 2005 Feb;114(2):225–234. doi: 10.1111/j.1365-2567.2004.02074.x

Table 1. The effect of treatment with lymphotoxin β-receptor immunoglobulin (LTβR-Ig) on the early accumulation of PrP^Sc in the inguinal lymph nodes and spleens of scrapie-inoculated mice^*^†.

	hu-Ig			LTβR-Ig

Day of treatment	Right ILN^‡	Left ILN^§	Spleen	Right ILN	Left ILN	Spleen
14	++	−	−	+/−	−	−
42	+++	+	+	+/−	−	+/−

Mice were given a single intraperitoneal (i.p.) injection (100 µg) of LT β R-Ig or polyclonal human immunoglobulin G (hu-Ig), as a control, on the days indicated after inoculation with scrapie via skin scarification of the right thigh.

^†

Tissues were taken 3 days after treatment, and the number of PrP^Sc-containing lymphoid follicles in inguinal lymph nodes (ILNs) and spleen from two mice was scored as follows: +++, ≥ 4 positive follicles; ++, 2–3 positive follicles; +, 1 positive follicle; +/−, 1 positive follicle in only one of the samples; −, no PrP^Sc detected.

^‡

Inguinal lymph node draining the site of inoculation.

^§

Non-draining inguinal lymph node.

Table 1. The effect of treatment with lymphotoxin β-receptor immunoglobulin (LTβR-Ig) on the early accumulation of PrPSc in the inguinal lymph nodes and spleens of scrapie-inoculated mice*†.

Table 1. The effect of treatment with lymphotoxin β-receptor immunoglobulin (LTβR-Ig) on the early accumulation of PrP^Sc in the inguinal lymph nodes and spleens of scrapie-inoculated mice^*^†.