Table 3. Effect of treatment with lymphotoxin β-receptor immunoglobulin (LTβR-Ig) on the accumulation of scrapie infectivity in the spleen 70 days after inoculation with scrapie via the skin^†.

	hu-Ig			LTβR-Ig
Day of treatment	Incidence‡	Mean incubation period (days) ± SE	Titre§	Incidence	Mean incubation period (days) ± SE	Titre
−3	9/9	187 ± 3	7·1	0/9	9× > 300	< 3·5
+14	8/8	188 ± 4	7·0	0/8	9× > 300	< 3·5
+42	9/9	202 ± 9	6·0	6/9	243 ± 5*, 3× > 300	≤ 4·1

^†Mice were given a single i.p. injection (100 µg) of LT β R-Ig or polyclonal human immunoglobulin G (hu-Ig) as a control on the days indicated after inoculation with scrapie via skin scarification of the right thigh. Spleens were pooled from two mice and infectivity levels were determined by intracerebral (i.c.) injection of lysates into groups of C57BL/Dk indicator mice.

^‡See Table 2, footnote^‡

^§See Table 2, footnote ^§

^*P < 0·02, when compared to the mean incubation period for hu-Ig control tissues.