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Effect of IL-16 on allergen-induced IL-13 production. PBMC were isolated from atopic donors (n = 11) and incubated for 6 days with culture medium, ragweed allergen extract, ragweed allergen extract plus rhIL-16 (100 ng/ml) or rhIL-16 alone. IL-13 release in cell culture supernatants was quantitated by ELISA. Results are expressed as the mean ± SEM. *P < 0·001 compared to cell cultures with culture medium only and cell cultures with allergen plus rhIL-16 (anova).
