Figure 4.

In vivo treatment with OX40–immunoglobulin (Ig) significantly delayed intestinal pathology during early infection with T. spiralis. The lengths of villi and crypts (a) were measured and the mean number of mitotic figures per crypt (b) determined at 7 and 14 days post infection (d.p.i.). The entire small intestine from infected and uninfected mice was weighed at 7 and 14 d.p.i. (c). *, significantly different from uninfected mice; †, significantly different from infected untreated mice (P < 0·05). Data are presented as mean villus/crypt length + standard error of the mean (SEM), mean number of mitotic figures + SEM and mean wet weight (g) + SEM, respectively. Five mice were used per group and the results shown are representative of two independent experiments.