Table 2.
Culture results from various organs of mice infected intravaginally with Chlamydia trachomatis mouse pneumonitis (MoPn)
| Mice (%) with positive cultures, and median (range) no. of C. trachomatis MoPn IFU recovered from: | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Small intestine | Large intestine | Spleen | Lungs | Kidneys | ||||||||
| Mice | Days p.i. | |||||||||||
| IFU (× 104) | % | IFU (× 104) | % | IFU | % | IFU | % | IFU | ||||
| MMP-7 WT | 5 | 100 | 15·5 (0·05–66·6) | 67 | 23·0 (0–37·5) | 0 | 0 | 0 | 0 | 0 | 0 (0–100) | |
| MMP-7 KO | 5 | 100 | 41·6 (2·9–263·0) | 100 | 25·0 (1·5–136·0) | 40 | 0 (0–75) | 0 | 0 | 0 | 0 | |
| MMP-7 WT | 15 | 100 | 0·5 (0·005–5·4) * | 100 | 18·7 (0·1–34·9) | 20 | 0 (0–4) | 20 | 0 (0–50) | 0 | 0 | |
| MMP-7 KO | 15 | 100 | 18·2 (4·9–3240·0) | 100 | 7·8 (4·1–900·0) | 0 | 0 | 0 | 0 | 20 | 0 (0–50) | |
| MMP-7 WT | 35 | 100 | 0·5 (0·2–1·0) | 100 | 240·0 (70·5–630·0) | 0 | 0 | 0 | 0 | 0 | 0 | |
| MMP-7 KO | 35 | 100 | 0·5 (0·1–1251·0) | 100 | 20·5 (20·0–348·0) | 0 | 0 | 0 | 0 | 0 | 0 | |
IFU, inclusion-forming units; KO, knockout; MMP, matrix metalloproteinase; p.i. postinfection; WT, wild type.
*
P < 0·05 (Mann–Whitney U-test).