Table 3.
Up-regulated transcripts in monocyte-derived dendritic cells (MoDCs) and MUTZ-3 dendritic cells (MUTZ-3-DCs) in response to inflammatory stimulation.
| MoDCs | MUTZ-3-DCs | ||||
|---|---|---|---|---|---|
| GenBank no. | Description | 0–8 hr | 0–48 hr | 0–8 hr | 0–48 hr |
| Cell adhesion | |||||
| NM_001627 | ALCAM | 6·5 | 2·8 | 2·4 | 3·2 |
| NM_015717 | CD207 | 5·1 | 1·0 | 1·3 | 7·7 |
| AA700015 | CD58 | 6·1 | 2·7 | 5·4 | 5·2 |
| NM_021101 | CLDN1 | 3·8 | −4·0 | 3·5 | 3·6 |
| AA292373 | COL6A1 | 2·9 | 1·4 | 4·0 | 3·6 |
| NM_030781 | COLEC12 | 2·6 | 1·1 | 1·0 | 2·3 |
| NM_000201 | ICAM-1 | 4·3 | 3·1 | 2·5 | 1·5 |
| NM_003622 | PPFIBP1 | 6·3 | 1·1 | 2·2 | −1·3 |
| Cell shape | |||||
| NM_019034 | ARHF | 9·0 | 6·2 | 3·2 | 2·4 |
| NM_002421 | MMP1 | 21·3 | 7·4 | 2·5 | 6·3 |
| NM_002425 | MMP10 | 340·0 | 61·6 | 8·2 | 3·1 |
| NM_004994 | MMP9 | 5·6 | −4·0 | 3·2 | 2·2 |
| Immune/inflammatory response | |||||
| BC006196 | 4-1BB | 50·7 | 47·3 | 4·2 | 1·1 |
| NM_002987 | CCL17, TARC | 4·3 | 4·4 | 4·4 | 6·1 |
| NM_002990 | CCL22, MDC | 16·2 | 15·0 | 10·7 | 12·9 |
| NM_002983 | CCL3, MIP-1a | 2·0 | −2·3 | 2·7 | −1·5 |
| NM_002984 | CCL4, MIP-1b | 3·3 | −8·0 | 2·9 | −2·1 |
| NM_002985 | CCL5, RANTES | 23·4 | 1·1 | 6·7 | 2·2 |
| NM_001838 | CCR7 | 54·2 | 59·6 | 9·9 | 44·6 |
| X60592 | CD40 | 5·1 | 3·1 | 2·4 | 1·5 |
| NM_001252 | CD70 | 9·0 | 10·5 | 4·4 | 4·4 |
| NM_005191 | CD80 | 4·1 | 2·9 | 2·2 | 2·4 |
| NM_004233 | CD83 | 10·0 | 7·3 | 10·4 | 12·6 |
| NM_001511 | CXCL1, Groα | 53·3 | 4·5 | 3·5 | 2·7 |
| M57731 | CXCL2, Groβ | 41·1 | 4·3 | 4·4 | 2·1 |
| AJ224869 | CXCR4 | 10·4 | 5·8 | 1·8 | 3·5 |
| NM_002349 | DEC205 | 6·6 | 11·2 | 1·8 | 10·1 |
| U62824 | HLA-C | 1·8 | 3·0 | 1·8 | 2·5 |
| BE138825 | HLA-F | 2·1 | 2·3 | 1·5 | 2·4 |
| M90686 | HLA-G | 2·0 | 3·1 | 2·5 | 3·8 |
| AF043337 | IL-8 | 56·5 | 10·3 | 2·5 | 1·9 |
| NM_001558 | IL-10RA | 2·0 | 1·4 | 2·6 | 2·7 |
| NM_002187 | IL-12Bp40 | 132·3 | 34·9 | 5·9 | 26·5 |
| NM_003855 | IL-18R1 | 54·5 | 8·5 | 3·0 | 1·3 |
| M15329 | IL-1A | 4·4 | 1·9 | 18·6 | 3·3 |
| M15330 | IL-1B | 21·3 | 3·4 | 6·0 | 3·6 |
| NM_000877 | IL-1R1 | 2·0 | 1·8 | 1·5 | 2·2 |
| BE563442 | IL-1RN | 31·9 | 2·3 | 6·6 | 2·4 |
| AF269133 | IL-21R | -1·3 | 3·0 | 2·3 | 3·4 |
| NM_016584 | IL-23A | 5·0 | 4·3 | 2·8 | 1·3 |
| NM_000600 | IL-6 | 34·3 | 1·9 | 2·3 | 2·8 |
| NM_002185 | IL-7R | 14·9 | 5·4 | 5·8 | 3·2 |
| AJ277151 | OX40 | 97·6 | 23·2 | 5·9 | 1·7 |
| NM_000958 | PTGER4 | 5·3 | 1·0 | 3·9 | 3·5 |
| NM_000963 | PTGS2 | 81·4 | 4·1 | 2·3 | 1·3 |
| Regulation of transcription | |||||
| NM_020183 | ARNTL2 | 7·3 | 8·5 | 3·1 | 2·1 |
| AL021977 | MAFF | 13·8 | 8·9 | 4·6 | 3·7 |
| NM_002908 | REL | 19·6 | 11·5 | 6·2 | 6·0 |
| NM_006509 | RELB | 5·4 | 4·8 | 3·7 | 4·5 |
| Signalling | |||||
| AB003476 | AKAP12 | 28·1 | −1·6 | 5·0 | 1·1 |
| M13436 | INHBA | 129·6 | 12·9 | 10·8 | 3·9 |
| M55643 | NFKB1 | 11·9 | 7·7 | 5·4 | 3·3 |
| NM_007115 | TNFAIP6 | 105·3 | 12·9 | 16·8 | 8·4 |
| M27281 | VEGF | 14·9 | 2·5 | 2·6 | 1·5 |
The fold change in expression level compared with the unstimulated control sample is shown and the transcripts are grouped according to their function based on information from the Gene OntologyTM (GO) Consortium (http://geneontology.org/).ICAM, intercellular adhesion molecule; IL, interleukin; TNF, tumour necrosis factor; HLA, human leucocyte antigen; MIP, macrophage inflammatory protein.