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. 2006 May;118(1):101–111. doi: 10.1111/j.1365-2567.2006.02346.x

Figure 1.

Figure 1

Natural killer T (NKT) cell-deficient mice showed impairment in the induction of oral tolerance to ovalbumin (OVA). (a) B6 and B6 CD1d–/– mice were fed OVA or phosphate-buffered saline (PBS) and immunized with OVA. OVA-specific immunoglobulin G (IgG) in serum and T-cell proliferation were measured 14 days after immunization. (b) Spleen cells (2 × 106) from DO11·10 mice were adoptively transferred into BALB/c or BALB/c CD1d–/– mice, which were then fed OVA or PBS and immunized with OVA. OVA-specific IgG in serum and immune cell proliferation were measured 8 days after immunization. Data are the mean ± standard error of the mean for three mice in each group. These results are taken from a representative experiment of three repeated experiments (***P < 0·0001). OD, optical density; TdR, Thymidine uptake rate.