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. 2006 May;118(1):101–111. doi: 10.1111/j.1365-2567.2006.02346.x

Figure 3.

Figure 3

Natural killer T (NKT) cell-deficient mice showed impairment in the induction of oral tolerance to high- and low-dose ovalbumin (OVA). Splenocytes from DO11·10 mice were transferred to BALB/c and BALB/c CD1d–/– mice who were fed high (250 mg) or low (1 mg) doses of OVA and immunized with OVA. OVA-specific immunoglobulin G (IgG) in serum (a) and T-cell proliferation (b) in BALB/c and BALB/c CD1d–/– mice fed 250 or 1 mg OVA were measured on day 14. (c) OVA-specific IgG in variously diluted sera was measured on day 21. Data are the mean ± standard error of the mean for three mice in each group. These results are taken from a representative experiment of three repeated experiments. Statistical analysis was performed using the prism 3·0 program (***P < 0·0001; **P < 0·001).