Table 2.
Comparison of mycobacterial growth and host response in Hc congenic mice infected with Mycobacterium avium 25291 180 days earlier
| C57BL/10.Hc1 | C57BL/10.Hc0 | |
|---|---|---|
| Mycobacterial loads (log10 CFU/organ) | ||
| Spleen | 9·16 ± 0·76 | 7·77 ± 0·281 |
| Liver | 9·01 ± 1·14 | 7·06 ± 0·841 |
| Lung | 8·29 ± 0·62 | 7·37 ± 0·45 |
| In vitro IFN-γ response2 | 860·1 ± 787·6 | 2457·0 ± 1582·9 |
| Spleen cell numbers (× 10−6) | ||
| CD4+ cells | 7·0 ± 2·8 | 6·6 ± 1·2 |
| CD8+ cells | 3·1 ± 2·0 | 3·0 ± 0·3 |
| CD19+ cells | 68·3 ± 36·9 | 70·5 ± 6·6 |
| CD11b+ cells | 21·9 ± 7·2 | 8·7 ± 1·21 |
1
P < 0·05 according to Student's t-test.
2
Amounts of IFN-γ in pg/ml of supernatants from spleen cell cultures stimulated in vitro with M. avium culture filtrate proteins. The amounts of IFN-γ in supernatants of nonstimulated cells were below detection levels.