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. 2006 Jul;118(3):413–424. doi: 10.1111/j.1365-2567.2006.02398.x

Figure 9.

Figure 9

Effect of the dual altered peptide ligand (APL) on the expression of apoptotic markers by lymph node (LN) cells of C57BL/6 mice with experimental autoimmune myasthenia gravis (EAMG). EAMG was induced in C57BL/6 mice by immunization with Torpedo acetylcholine receptor (TAChR). After 4 weeks of treatment with either phosphate-buffered saline (PBS) (vehicle) or the dual APL, popliteal LN cells were harvested of four mice of each of the treatment groups. Total RNA was extracted from lymph node cells and real time polymerase chain reaction (PCR) was performed for caspase 8 and cFLIP expression as described in Materials and methods. Results are expressed as mean percentage gene expression of triplicates ± SD values. *P < 0·001, **P < 0·005 when gene expression of the dual APL-treated mice was compared with that of PBS-administered mice.