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Effect of histamine on nerve growth factor (NGF) production and inhibition by desloratadine as a H1 receptor antagonist. The XB-2 cell line was precultured with 0, 4, 20, 100 and 500 nm of loratadine, and then cultured with 100 mm of histamine for 24 hr. The cell-free culture supernatants were assayed for NGF measurement. Each value represents the mean and standard deviation.
