Table 1.
Histopathological examination of joints
| Synovitis | Bone/cartilage destruction | |||
| IL-12 status | Frequency (%) | Index | Frequency (%) | Index |
| IL-12-/- | 75 | 3.7 ± 0.9 | 63 | 3.4 ± 1.0 |
| IL-12+/+ | 89 | 5.2 ± 1.2 | 78 | 6.2 ± 1.7 |
Histopathological examination of joints from IL-12-deficient mice (n = 16) and their wild-type counterparts (n = 9) 20 days after intravenous inoculation of 1 × 107 staphylococci/mouse. All four limbs were sectioned and stained with haematoxylin and eosin. Synovial hypertrophy or bone/cartilage destruction was given a score of 1–3 for each joint location (elbow, wrist, carpal joints, fingers, knee, ankle, tarsal joints and toes). Values are expressed as percentage or mean ± standard error or the mean.