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. 2006 Jul;118(3):353–360. doi: 10.1111/j.1365-2567.2006.02379.x

Figure 4.

Figure 4

Relative contribution of the CD28/B7 and ICOS/ICOS-L pathways for the costimulation of T cells interacting with PDC versus moDC. CD4+ CD45RO+ T cells from a given donor were cocultured with (a) mature PDC or (b) mature moDC for 48 hr in the presence of SEB and the cytokine levels were determined by ELISA. The ICOS costimulation pathway was blocked with anti-ICOS-L mAb HIL-131, the CD28 pathway was blocked with CTLA-4Ig, an isotype control mAb was also used. In each experiment, the cytokine level observed in the medium control was set as 100%. The data shown represent two to eleven experiments.