Table 1.
Interferon-gamma (IFN-γ)-positive T cells in the central nervous system (CNS) of mice with EAE
| Unstimulated | Anti-CD3 stimulated | |||
|---|---|---|---|---|
| IFN-c+ T cells | Total T cells | IFN-c+ T cells | Total T cells | |
| % Total cells | ||||
| Wild-type | 0·7 ± 0·4% | 12·6 ± 4·3% | 2·1 ± 1·0% | 11·9 ± 5·3% |
| TNFR1–/– | 1·3 ± 0·4% | 22·9 ± 3·5% | 6·5 ± 3·9% | 20·8 ± 6·2% |
| Significance | P < 0·01 | P < 0·001 | P < 0·01 | P < 0·01 |
| Fold increase | 1·9 | 1·8 | 3·1 | 1·7 |
| No. of cells (× 103) | ||||
| Wild-type | 7·3 ± 3·4 | 130·1 ± 100·4 | 20·0 ± 4·6 | 119·2 ± 116·0 |
| TNFR1–/– | 18·3 ± 9·6 | 346·9 ± 253·6 | 53·0 ± 19·1 | 301·0 ± 222·1 |
| Significance | P < 0·01 | P < 0·005 | P < 0·01 | P < 0·07 |
| Fold increase | 2·5 | 2·7 | 2·7 | 2·5 |
Results shown are mean ± s.d., n = 6–10 mice. TNFR1 –/–: tumour necrosis factor receptor.