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. 2006 Sep 1;119(1):8–17. doi: 10.1111/j.1365-2567.2006.02383.x

Figure 4.

Figure 4

SOCS3 regulates IL-10 suppression of LPS-induced TNF-α production at 2 hr. Monocytes were left uninfected or infected with either AdV-GFP or AdV-SOC3 for 24 h prior to stimulation with LPS (solid bars) and LPS + IL-10 (open bars). TNF-α levels were measured in culture supernatants at (a) 2 hr and (b) 24 hr following stimulation. Data are represented as the TNF-α levels (ng/ml) as well as the mean percentage suppression by IL-10 of LPS-induced TNF-α. Values are the mean ± SEM of seven experiments for 2 hr analysis or nine experiments for 24 hr. Statistical significance was calculated using a one-way anova (*P < 0·05, ns = not significant).