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SOCS3-regulation of IL-10 activity depends on the level of SOCS3 expression per cell. Monocytes were infected with AdV-GFP and AdV-SOCS3 (MOI 50) for 24 hr and the GFP-mean fluorescence intensity (MFI) determined using flow cytometry. The mean percentage suppression in TNF-α production observed 2 hr after cotreatment with LPS and IL-10 was plotted against MFI. Each graphed value represents one experiment (n = 3 within each experiment).
