Figure 2.

Suppression of arthritis development by neutrophil depletion. The mice were intravenously injected with anti-CII mAb on day 0, RB6-8C5 mAb (▴) or isotype mAb (○) on day 2 (arrow), and with LPS on day 3 (arrowhead) (a). The severity of the arthritis was judged using the sum arthritis scores of both fore and hind paws, as described in Materials and methods. The sum scores (maximum score: 12) were expressed as the mean ± SEM of the five mice in each group. On day 7, the hind paws of the mice injected with isotype mAb (b) or RB6-8C5 mAb (c) were removed and stained with haematoxylin and eosin. The original magnification of both photographs was ×50.