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. 2006 Oct;119(2):195–202. doi: 10.1111/j.1365-2567.2006.02424.x

Figure 4.

Figure 4

Amelioration of the maintaining of arthritis by neutrophil depletion. The mice were injected with anti-CII mAb on day 0 and with LPS on day 3. On day 7, arthritis-developed mice were picked up (uninjected: ▵), and were injected with RB6-8C5 mAb (▴) and isotype mAb (○) (arrow) (a). The severity of arthritis was judged using the sum arthritis scores of both fore and hind paws as described in Materials and methods. The sum scores (maximum score: 12) were expressed as the mean ± SEM of the five mice. The sum scores of the RB6-8C5 mAb-injected mice are significantly different from those of the isotype mAb-injected mice (*P < 0·05; **P < 0·01). Histological sections of the tarsal joints of the mice stained with haematoxylin and eosin are shown (b–d). The isotype mAb-injected mice on day 11 (original magnification, b: ×100, d: ×500) and the RB6-8C5 mAb-injected mice on day 11 (c: ×100). (d) A photograph of the inset in (b) at higher magnification, arrows indicate infiltrated neutrophils.