Figure 6.

Suppression of arthritis development and amelioration of established arthritis by Ptx injection. The mice were intravenously injected with anti-CII mAb on day 0, and with LPS on day 3. One hr before the LPS-injection, the mice were intravenously injected with Ptx (0·5 µg/0·2 ml/body) (▴) or saline (○) (arrow) (a). The mice were injected with anti-CII mAb on day 0, and with LPS on day 3. On day 7, arthritis-developed mice whose sum arthritis scores were 12 were selected (untreated: ▵), and were injected with Ptx (▴) or saline (○) (arrow) (b). The severity of the arthritis was judged using the sum arthritic scores of both fore and hind paws, as described in Materials and methods. The sum of scores (maximum score: 12) were expressed as the mean ± SEM of the five mice in each group. The sum scores of the Ptx-injected mice were significantly different from those of the saline-injected mice (*P < 0·05; **P < 0·01).