Table 1.
Cellularity in the synovial membranes of the normal mice or mice induced with arthritis by the injection of both anti-CII mAb and LPS
| Untreated | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | |
| Neutrophil | – | – | – | – | – | – | – | – | – | – | – | + | + | + | – | ++ | ++ | +++ | + | ++ | +++ | + | – | + |
| Lymphocyte | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Macrophage | – | – | – | – | – | – | – | – | – | – | + | – | + | + | + | + | + | + | + | + | + | + | + | + |
Arthritis was induced using the same procedure as Fig. 1. Three mice were killed each day and histological sections were made. The cellularity was graded as follows: –, normal; +, slight change; ++, mild change; +++, severe change.