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Incidence and severity of arthritis in knees of IL-12 knockout mice (IL-12–/–) (n = 8) in comparison with their wild-type littermates (IL-12+/+) (n = 9), 3 d after intra-articular inoculation with 6 μg CpG ODN. (a) Incidence. (b) Severity. NS = not significant.
