Table 1.
Amino acid sequences encoded by the mouse Ins2 and Ins1 genes
| 1–24 Signal peptide (n = 6; residues 4, 5, 6, 15, 19, 20) | |
| ″Ins2 | MALWMRFLPLLALLFLWESHPTQA |
| ″Ins1 | MALLVHFLPLLALLALWEPKPTQA |
| 25–54 B chain (n = 3; residues 33, 37, 53) | |
| ″Ins2 | FVKQHLCGSHLVEALYLVCGERGFFYTPMS |
| ″Ins1 | FVKQHLCGPHLVKALYLVCGERGFFYTPKS |
| 55–56 | |
| ″Ins2 | RR |
| ″Ins1 | RR |
| 57–87 C-peptide (n = 5; residues 64, 71, 74, 75, 86) | |
| ″Ins2 | EVEDPQVAQLELGGGPGAGDLQTLALEVAQQ |
| ″Ins1 | EVEDPQVEQLELGGSPG**DLQTLALEVARQ |
| 88–89 | |
| ″Ins2 | KR |
| ″Ins1 | KR |
| 90–110 A-chain | |
| ″Ins2 | GIVDQCCTSICSLYQLENYCN |
| ″Ins1 | GIVDQCCTSICSLYQLENYCN |
Amino acid sequences encoded by the Ins2 (top) and Ins1 (bottom) genes are shown.58 Amino acid residues that differ between the two sequences are underlined.