Table 5.
Hydroxyproline content in liver tissue of CBA/J mice infected with Schistosoma mansoni and treated with praziquantel
| Months after treatment | Control (µg/g tissue) | Praziquantel (µg/g tissue) |
|---|---|---|
| Normal, uninfected | 165.06 ± 25.50 | |
| (3) | ||
| Untreated, 8 weeks | 472.67 ± 91.98 | |
| post-infection | (4) | |
| 3 | 1131.69 ± 151.42 | 867.12 ± 125.30 |
| (6)a | (7) | |
| 6 | 1608.97 ± 129.10 | 648.65 ± 52.11* |
| (9) | (13) | |
| 12 | ND | 460.89 ± 39.27* |
| (7) |
The results are presented as mean ± SEM.
a
Values in parentheses are numbers of mice used.
Mice treated with praziquantel for 12 months were compared with untreated controls at 6 months.
*
Significant at the P < 0·0001 level compared with controls.