Figure 2.

Synergism between pre- and postinfection inoculated IgA. BALB/c mice were intranasally inoculated with affinity purified TBA61 IgA (4 mg/ml; anti-acr) 3 hr before and 3 days after H37Rv aerosol infection. Columns represent mean values (n = 8) and bars are standard errors of CFU counts 9 days after infection. TBA61 inoculation regime in relation to M. tuberculosis H37Rv challenge: open: MOPC315 IgA myeloma (exp.1) or PBS (exp. 2 and 3) controls; grey, −3 hr; hatched, +3 days; black, −3 hr and +3 days. The data for three independent experiments are shown. The reduction in lung CFU following two doses of TBA61 was significantly different from the control MOPC315 or PBS groups, respectively, in all three experiments (P < 0·01, anova test with multiple comparison of means using Fisher's method).