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. 2004 Apr;111(4):407–415. doi: 10.1111/j.1365-2567.2004.01822.x

Figure 5.

Figure 5

Phosphatidylinositol 3-kinase (PI3K) activation is involved in interleukin-8 (CXCL8)-induced human polymorphonuclear neutrophil (PMN) chemotaxis. PMNs were preincubated with vehicle or LY294002 (25 µm or 50 µm) for 15 min at 37°. Cells were then tested for their ability to migrate in response to CXCL8 (10 ng/ml). Data are expressed as mean values ± standard deviation (SD) of three independent experiments. Spontaneous PMN migration: 23 ± 5 **P < 0·01 versus CXCL8 alone (Mann–Whitney U-test).