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Negative regulation of T-cell signalling by phosphoprotein associated with GEMS (PAG). PAG is constitutively tyrosine-phosphorylated in resting T cells, and associates with Csk, a negative regulator of Scr kinases, via its SH2 domain. Following T-cell receptor (TCR) engagement, PAG is dephosphorylated by a PTPase, most likely CD45. This leads to the dissociation of Csk, which relieves Src kinases of inhibition, enabling them to transmit signals downstream.
