Figure 2.

T cell (LTT, IFN-γ and IL-10) and B cell (IgG1–IgG4) antibody responses to the overlapping 15-mer peptides of ML GroES. Results are expressed as percentage giving a positive signal (determined as described in Materials and methods section). Solid lines indicate T cell responses and broken lines indicate B cell responses. Responses for leprosy patients [lepromatous (a) and tuberculoid leprosy (b)], healthy endemic controls (c) and pulmonary tuberculosis patients (d) are compared. The number in each group is shown in brackets next to the group. The symbol for each parameter is identical in the four panels. The x-axis shows the stimulating peptides. Prefix T/l before the peptides indicates that the peptide is shared with the M. tuberculosis (MT) GroES homologue. Prefix L indicates that this peptide has amino acid interchanges in the MT homologue.